Manchester City will take on Real Madrid for a fifth straight season in the knockout stages of the UEFA Champions League, while Chelsea have been drawn against holders Paris Saint-Germain in a blockbuster last-16 tie.
Despite six Premier League clubs reaching the knockout phase, there are no all-English clashes.
League-phase leaders Arsenal will face Bayer Leverkusen, while Newcastle United meet Barcelona.
Liverpool have been paired with Galatasaray, and Tottenham Hotspur will take on Atletico Madrid.
The first legs are scheduled for March 10 and 11, with return fixtures on March 17 and 18.
Newcastle will host Barcelona in their opening leg, while their Premier League rivals are set to play the second legs at home after qualifying automatically for the last 16.
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Chelsea’s showdown with PSG is a rematch of last year’s FIFA Club World Cup final, where the Blues triumphed 3-0 in New Jersey.
City’s clash with Real Madrid adds another chapter to an increasingly familiar European rivalry, with the English champions having faced the Spanish giants nine times since April 2022.
The route to the final, set for the Puskas Arena in Budapest on May 30, is already mapped out.
If Newcastle and Tottenham progress, they will meet in the quarter-finals, while Chelsea and Liverpool could collide in the other half of the draw.
Opta’s projections rate Arsenal as favourites to lift the trophy for the first time, ahead of Bayern Munich, with Liverpool and Manchester City also strongly fancied.
Record 15-time champions Real Madrid are considered outsiders by comparison.
In the Europa League, Nottingham Forest will face FC Midtjylland, while Aston Villa meet Lille OSC.
Meanwhile, Crystal Palace, the Premier League’s sole representative in the Conference League, has been drawn against AEK Larnaca.
The first and second legs of the Europa League and Conference League ties will be played on March 12 and 19, setting up a decisive fortnight in European football.
